Three-dimensional spatiotemporal tracking of fluorine-18 radiolabeled yeast cells via positron emission particle tracking

Seth T Langford, Cody S Wiggins, Roque Santos, Melinda Hauser, Jeffrey M Becker and Arthur E Ruggles

PLOS ONE, 2017, vol. 12, issue 7, 1-14

Abstract: A method for Positron Emission Particle Tracking (PEPT) based on optical feature point identification techniques is demonstrated for use in low activity tracking experiments. A population of yeast cells of approximately 125,000 members is activated to roughly 55 Bq/cell by 18F uptake. An in vitro particle tracking experiment is performed with nearly 20 of these cells after decay to 32 Bq/cell. These cells are successfully identified and tracked simultaneously in this experiment. This work extends the applicability of PEPT as a cell tracking method by allowing a number of cells to be tracked together, and demonstrating tracking for very low activity tracers.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0180503

DOI: 10.1371/journal.pone.0180503

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