Sex-specific mortality differences in heart failure patients with ischemia receiving cardiac resynchronization therapy

Zhonglin Han, Zheng Chen, Rongfang Lan, Wencheng Di, Xiaohong Li, Hongsong Yu, Wenqing Ji, Xinlin Zhang, Biao Xu and Wei Xu

PLOS ONE, 2017, vol. 12, issue 7, 1-17

Abstract: Background: Recent studies have reported prognosis differences between male and female heart failure patients following cardiac resynchronization therapy (CRT). However, the potential clinical factors that underpin these differences remain to be elucidated. Methods: A meta-analysis was performed to investigate the factors that characterize sex-specific differences following CRT. This analysis involved searching the Medline (Pubmed source) and Embase databases in the period from January 1980 to September 2016. Results: Fifty-eight studies involving 33445 patients (23.08% of whom were women) were analyzed as part of this study. Only patients receiving CRT with follow-up greater than six months were included in our analysis. Compared with males, females exhibited a reduction of 33% (hazard ratio, 0.67; 95% confidence interval, 0.62–0.73; P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0180513

DOI: 10.1371/journal.pone.0180513

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