Can a tablet-based cancellation test identify cognitive impairment in older adults?

Ya-Huei Wu, Jean-Sébastien Vidal, Jocelyne de Rotrou, Sietske A M Sikkes, Anne-Sophie Rigaud and Matthieu Plichart

PLOS ONE, 2017, vol. 12, issue 7, 1-14

Abstract: Background and objective: There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based cancellation test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods: The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T test, a paper-and-pencil cancellation test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T test to classify subjects into diagnostic groups. Results: In the MCI group, age (B = -0.37, p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0181809

DOI: 10.1371/journal.pone.0181809

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