Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis

Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen and Kuei-Ru Chou

PLOS ONE, 2017, vol. 12, issue 8, 1-14

Abstract: Background: This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive functions, behavioral and psychological symptoms in dementia (BPSD), and global functions. Methods: PubMed, Medline, Embase, PsycINFO, and Cochrane databases were used to search for English and non-English articles for inclusion in the meta-analysis to evaluate the effect size and incidence of adverse drug reactions of different treatments. Results: Compared with patients who received donepezil alone, those who received donepezil in combination with memantine exhibited limited improvements in cognitive functions (g = 0.378, p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0183586

DOI: 10.1371/journal.pone.0183586

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