Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study

Saeda Haj, Gabriel Chodick, Rotem Refaeli, Sophy Goren, Varda Shalev and Khitam Muhsen

PLOS ONE, 2017, vol. 12, issue 8, 1-13

Abstract: Background: Evidence is conflicting regarding the association between Helicobacter pylori infection and diabetes mellitus. The study objective was to examine associations of H. pylori infection, gastric ulcers and duodenal ulcers, with diabetes mellitus. Methods: This cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel, on 147,936 individuals aged 25–95 years who underwent the urea breath test during 2002–2012. Multiple logistic regression models were conducted, while adjusting for known risk factors for diabetes mellitus. Results: A H. pylori positive test was recorded for 76,992 (52.0%) individuals and diabetes for 12,207 (8.3%). The prevalence of diabetes was similar in individuals with and without H. pylori infection, but this association was modified (P for heterogeneity 0.049) by body mass index (BMI): adjusted odds ratio (aOR) 1.16 (95% confidence intervals (CI) 1.04–1.29) in persons with BMI

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0183687

DOI: 10.1371/journal.pone.0183687

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