Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort

Shou-Chien Hsu, Shy-Shin Chang, Meng-tse Gabriel Lee, Si-Huei Lee, Yi-Wen Tsai, Shen-Che Lin, Szu-Ta Chen, Yi-Chieh Weng, Lorenzo Porta, Jiunn-Yih Wu and Chien-Chang Lee

PLOS ONE, 2017, vol. 12, issue 9, 1-14

Abstract: Background: Fluoroquinolone is a commonly prescribed antimicrobial agent, and up to 20% of its users registers adverse gastroenterological symptoms. We aimed to evaluate the association between use of fluoroquinolone and gastrointestinal tract perforation. Methods: We conducted a nested case-control study on a national health insurance claims database between 1998 and 2011. The use of fluoroquinolones was classified into current (

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0183813

DOI: 10.1371/journal.pone.0183813

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