Establishing contemporary trends in hepatitis B sero-epidemiology in an Indigenous population

Jane Davies, Shu Qin Li, Steven Y Tong, Rob W Baird, Miles Beaman, Geoff Higgins, Benjamin C Cowie, John R Condon and Joshua S Davis

PLOS ONE, 2017, vol. 12, issue 9, 1-13

Abstract: Background: Indigenous populations globally are disproportionately affected by chronic hepatitis B virus (HBV) infection however contemporary sero-prevalence data are often absent. In the Indigenous population of the Northern Territory (NT) of Australia the unique C4 sub-genotype of HBV universally circulates. There are no studies of the sero-prevalence, nor the impact of the vaccination program (which has a serotype mismatch compared to C4), at a population-wide level. Methods: We examined all available HBV serology results obtained from the three main laboratories serving NT residents between 1991 and 2011. Data were linked with a NT government database to determine Indigenous status and the most recent test results for each individual were extracted as a cross-sectional database including 88,112 unique individuals. The primary aim was to obtain a contemporary estimate of HBsAg positivity for the NT by Indigenous status. Results: Based on all tests from 2007–2011 (35,633 individuals), hepatitis B surface antigen (HBsAg) positivity was 3·40% (95%CI 3·19–3·61), being higher in Indigenous (6·08%[5·65%-6·53%]) than non-Indigenous (1·56%[1·38%-1·76%]) Australians, p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0184082

DOI: 10.1371/journal.pone.0184082

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