Natural course of the nodular bronchiectatic form of Mycobacterium Avium complex lung disease: Long-term radiologic change without treatment

Tae Yun Park, Semin Chong, Jae-Woo Jung, In Won Park, Byoung Whui Choi, Changwon Lim, Chang Un Lee, Yang Soo Kim, Hye Won Choi and Jae Chol Choi

PLOS ONE, 2017, vol. 12, issue 10, 1-11

Abstract: Background/Purpose: Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described. The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. Methods: Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6.23 years). Majority of patients have minimal symptoms. Two chest radiologists retrospectively reviewed initial and final chest CT scans. Each chest CT scan was scored for presence and extent of bronchiectasis, cellular bronchiolitis, consolidation, cavity, and nodule (maximum score: 30). Results: Of 40 patients, 39 (97.5%) experienced a significant increase in overall CT score (overall difference = 4.89, p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0185774

DOI: 10.1371/journal.pone.0185774

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