Incident osteoarthritis and osteoarthritis-related joint replacement surgery in patients with ankylosing spondylitis: A secondary cohort analysis of a nationwide, population-based health claims database

Ming-Chi Lu, Chien-Hsueh Tung, Chang-Chen Yang, Chun-Lung Wang, Kuang-Yung Huang, Malcolm Koo and Ning-Sheng Lai

PLOS ONE, 2017, vol. 12, issue 11, 1-9

Abstract: Background: Ankylosing spondylitis (AS) might be associated with an increased risk of secondary osteoarthritis. However, there is a lack of studies assessing its impact on osteoarthritis-related surgery. The aim of this secondary cohort study was to investigate the risk of symptomatic osteoarthritis and osteoarthritis-related surgery, including total hip replacement surgery (THRS) and total knee replacement surgery (TKRS) in patients with AS. Methods: Using the Taiwan’s National Health Insurance Research Database, we identified 3,462 patients with AS between 2000 and 2012. A comparison cohort was assembled consisting of five patients without AS, based on frequency matching for sex, 10-year age interval, and index year, for each patient with AS. Both groups were followed until diagnosis of the study outcomes or the end of the follow-up period. Results: Male patients with AS exhibited a significantly higher incidence of osteoarthritis (adjusted incidence rate ratio [IRR] 1.43; P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0187594

DOI: 10.1371/journal.pone.0187594

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