Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis

Yue Dong, Sebastian Ochsenreither, Chengxuan Cai, Andreas M Kaufmann, Andreas E Albers and Xu Qian

PLOS ONE, 2017, vol. 12, issue 11, 1-13

Abstract: There is a lack of predictive biomarkers that can identify patients with head and neck squamous cell carcinoma (HNSCC) who will experience treatment failure and develop drug resistance, recurrence, and metastases. Cancer stem-like cells (CSC) were identified as a subset of cells within the tumor in a variety of solid tumors including HNSCC. CSC are considered the tumor-initiating population responsible for recurrence or metastasis and are associated with therapy resistance. This meta-analysis including fourteen studies with altogether 1258 patients updates and summarizes all relevant data on the impact of ALDH1+ CSC on the prognosis of HNSCC and its association with clinicopathological parameters. ALDH1 expression is highly correlated with tumor differentiation (G3 vs. G1+G2; odds ratio = 2.85. 95% CI: 1.72–4.73, P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0187615

DOI: 10.1371/journal.pone.0187615

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