Elevated N-telopeptide as a potential diagnostic marker for bone metastasis in lung cancer: A meta-analysis

Boxuan Liu, Yun Zhao, Jingyan Yuan, Lizhong Zeng, Ruiying Sun, Xia Meng and Shuanying Yang

PLOS ONE, 2017, vol. 12, issue 11, 1-12

Abstract: Background: Growing evidence indicates that the cross-linked N-telopeptide of type I collagen (NTx) is likely to be involved in the development of bone metastasis among lung cancer patients. We perform a meta-analysis to disclose the correlation between bone metastasis and NTx and also to evaluate its value in diagnosis of bone metastasis (BM) in lung cancer. Method: Electronic databases were searched and calculated the weighted mean difference (WMD) with 95% confidence interval (CI) to assess the expression difference of NTx between BM+ and BM- lung cancer patients. Moreover, we conducted a sensitivity and specificity test and drew a summary receiver operating characteristic curve (SROC) to assess the diagnostic value of NTx in discerning bone metastasis. Results: A total of eleven studies with 1108 individuals were included in this analysis. The results showed an increased NTx was correlated with the incidence of lung cancer (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0187860

DOI: 10.1371/journal.pone.0187860

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