Decreased prevalence of cancer in patients with multiple sclerosis: A case-control study

Xavier Moisset, Maud Perié, Bruno Pereira, Emilie Dumont, Christine Lebrun-Frenay, François-Xavier Lesage, Frederic Dutheil, Frederic Taithe and Pierre Clavelou

PLOS ONE, 2017, vol. 12, issue 11, 1-11

Abstract: Background: Studies of cancer prevalence have produced conflicting results concerning the relative risk of overall and specific sub-types of cancer in patients with multiple sclerosis (MS). Contemporary controls and information on tobacco use and alcohol consumption are generally missing from previous studies. Objectives: To evaluate lifetime cancer prevalence in a large cohort of MS patients relative to appropriate controls. Methods: We conducted a case-control study, using a postal survey of a cohort of MS patients. Of the 1574 questionnaires sent, 1107 could be used for statistical analysis. Data from 1568 controls were prospectively collected using the same self-administered survey among consecutive out-patients in a single neurology department. Propensity scores matched on age, gender, and history of smoking and alcohol consumption were calculated. Results: Among the MS patients, 7.32% had ever presented with a cancer, whereas 12,63% of the controls had, leading to a bootstrap matched odds ratio (OR) of 0.63; 95% CI 0.57–0.70. Although only exploratory, the use of DMT (immunomodulators or immunosupressants) did not appear to increase this risk (p = 0.42). The disease course also did not affect cancer prevalence. Conclusion: MS was associated with a reduced overall cancer risk.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0188120

DOI: 10.1371/journal.pone.0188120

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