Proportion and factors associated with recent HIV infection in a cohort of patients seen for care in Italy over 1996-2014: Data from the ICONA Foundation Study cohort

Silvia Nozza, Alessandro Cozzi-Lepri, Francesca Bai, Stefano Rusconi, Andrea Gori, Paola Cinque, Adriana Ammassari, Pietro Caramello, Giuseppe Tambussi, Antonella D’Arminio Monforte, Giulia Marchetti and on behalf of Icona Foundation Study Group

PLOS ONE, 2017, vol. 12, issue 12, 1-16

Abstract: In Italy the prevalence of recent HIV infection (RHI) isn’t currently monitored. Early diagnosis is crucial to allow introduction of antiretroviral therapy (cART) in the recent phase of infection. We aimed to estimate the proportion and the determinants of RHI among patients enrolled in the ICONA cohort; we explored differences in the median time from HIV diagnosis to cART initiation and in the viro-immunological response between RHI and Less Recent HIV infections (NRHI). We included antiretroviral-naïve HIV-positive patients enrolled in the cohort with documented dates of HIV-negative and positive antibodies tests, grouped in RHI (estimated date of seroconversion within 12 months of enrolment) and NRHI. Proportion of RHI and the trend of this proportion by calendar period (1996–2014) were investigated (Chi-square test). Logistic regression analysis was employed to identify factors associated with RHI. The time from seroconversion to cART initiation was compared in RHI and NRHI overall and after stratification by calendar period (survival analysis). We finally explored the time from starting cART to HIV-RNA

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0189045

DOI: 10.1371/journal.pone.0189045

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