Factors influencing psychological well-being in patients with Parkinson’s disease

Alessandra Nicoletti, Giovanni Mostile, Fabrizio Stocchi, Giovanni Abbruzzese, Roberto Ceravolo, Pietro Cortelli, Marco D’Amelio, Maria F De Pandis, Giovanni Fabbrini, Claudio Pacchetti, Gianni Pezzoli, Alessandro Tessitore, Margherita Canesi and Mario Zappia

PLOS ONE, 2017, vol. 12, issue 12, 1-8

Abstract: Background: Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. Objectives: To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. Methods: This article reports data of patients’ perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL. Results: 272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson’s Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores. Conclusions: Non-motor symptoms have a significant impact on psychological well-being in PD patients.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0189682

DOI: 10.1371/journal.pone.0189682

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