The impact of persistent bacterial bronchitis on the pulmonary microbiome of children

Leah Cuthbertson, Vanessa Craven, Lynne Bingle, William O C M Cookson, Mark L Everard and Miriam F Moffatt

PLOS ONE, 2017, vol. 12, issue 12, 1-13

Abstract: Introduction: Persistent bacterial bronchitis (PBB) is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial microbiota of healthy children and to assess the impact of the changes associated with the development of PBB. Results: No significant difference in bacterial diversity or community composition (R2 = 0.01, P = 0.36) was observed between paired blind and non-blind brushes, showing that blind brushings are a valid means of accessing the airway microbiota. This has important implications for collecting lower respiratory samples from healthy children. A significant decrease in bacterial diversity (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0190075

DOI: 10.1371/journal.pone.0190075

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