Do blast induced skull flexures result in axonal deformation?

Harsha T Garimella, Reuben H Kraft and Andrzej J Przekwas

PLOS ONE, 2018, vol. 13, issue 3, 1-24

Abstract: Subject-specific computer models (male and female) of the human head were used to investigate the possible axonal deformation resulting from the primary phase blast-induced skull flexures. The corresponding axonal tractography was explicitly incorporated into these finite element models using a recently developed technique based on the embedded finite element method. These models were subjected to extensive verification against experimental studies which examined their pressure and displacement response under a wide range of loading conditions. Once verified, a parametric study was developed to investigate the axonal deformation for a wide range of loading overpressures and directions as well as varying cerebrospinal fluid (CSF) material models. This study focuses on early times during a blast event, just as the shock transverses the skull (

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0190881

DOI: 10.1371/journal.pone.0190881

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