A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain

Shima Ghasemi-Roudsari, Abbas Al-Shimary, Benjamin Varcoe, Rowena Byrom, Lorraine Kearney and Mark Kearney

PLOS ONE, 2018, vol. 13, issue 1, 1-10

Abstract: Background: Magnetocardiography (MCG) is a non-invasive technique used to measure and map cardiac magnetic fields. We describe the predictive performance of a portable prototype magnetometer designed for use in acute and routine clinical settings. We assessed the predictive ability of the measurements derived from the magnetometer for the ruling-out of healthy subjects and patients whose chest pain has a non-ischemic origin from those with ischemic heart disease (IHD). Methods: MCG data were analyzed from a technical performance study, a pilot clinical study, and a young healthy reference group. Participants were grouped to enable differentiation of those with IHD versus non-IHD versus controls: Group A (70 IHD patients); Group B (69 controls); Group C (37 young healthy volunteers). Scans were recorded in an unshielded room. Between-group differences were explored using analysis of variance. The ability of 10 candidate MCG predictors to predict normal/abnormal cases was analyzed using logistic regression. Predictive performance was internally validated using repeated five-fold cross-validation. Results: Three MCG predictors showed a significant difference between patients and age-matched controls (P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0191241

DOI: 10.1371/journal.pone.0191241

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