Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis

Hyun Suk Yang, Mina Hur, Ahram Yi, Hanah Kim, Seungho Lee and Soo-Nyung Kim

PLOS ONE, 2018, vol. 13, issue 1, 1-12

Abstract: Objective: Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis. Methods: We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of (‘presepsin’ or ‘sCD14-ST’ or ‘soluble CD14 subtype’) and (‘sepsis’ or ‘septic shock’) and (‘prognosis’ or ‘prognostic value’ or ‘prognostic biomarker’ or ‘mortality’). We extracted the presepsin levels in survivors and non-survivors from each individual study and evaluated the standardized mean difference (SMD) using a web-based meta-analysis with the R statistical analysis program. Results: A total of 10 studies and 1617 patients were included. Presepsin levels in the first sampling (within 24 hours) were significantly lower among survivors as compared with non-survivors: the pooled SMD between survivors and non-survivors was 0.92 (95% CI: 0.62–1.22) in the random effects model (I2 = 79%, P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0191486

DOI: 10.1371/journal.pone.0191486

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