The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage

Tetsuo Ikezono, Tomohiro Matsumura, Han Matsuda, Satomi Shikaze, Shiho Saitoh, Susumu Shindo, Setsuo Hasegawa, Seung Ha Oh, Yoshiaki Hagiwara, Yasuo Ogawa, Hiroshi Ogawa, Hiroaki Sato, Tetsuya Tono, Ryuichiro Araki, Yukihide Maeda, Shin-ichi Usami and Yasuhiro Kase

PLOS ONE, 2018, vol. 13, issue 1, 1-11

Abstract: Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness, disequilibrium, aural fullness, tinnitus, and cognitive dysfunction. By sealing the fistula, perilymphatic fistula is a surgically correctable disease. Also, appropriate recognition and treatment of perilymphatic fistula can improve a patient’s condition and hence the quality of life. However, the difficulty in making a definitive diagnosis due to the lack of an appropriate biomarker to detect perilymph leakage has caused a long-standing debate regarding its management. We have reported a clinical test for the diagnosis of perilymphatic fistula by detecting a perilymph specific protein, Cochlin-tomoprotein, as a diagnostic marker using a western blot. The aim of this study is to establish an ELISA-based human Cochlin-tomoprotein detection test and to evaluate its diagnostic accuracy in clinical subjects. The results of ELISA showed good dilution reproducibility. The mean concentration was 49.7±9.4 of 10 perilymph samples. The ROC curve in differentiating the perilymph leakage condition from the normal middle ear was significant (P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0191498

DOI: 10.1371/journal.pone.0191498

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