The impact of “Option B” on HIV transmission from mother to child in Rwanda: An interrupted time series analysis

Monique Abimpaye, Catherine M Kirk, Hari S Iyer, Neil Gupta, Eric Remera, Placidie Mugwaneza and Michael R Law

PLOS ONE, 2018, vol. 13, issue 2, 1-7

Abstract: Background: Nearly a quarter of a million children have acquired HIV, prompting the implementation of new protocols—Option B and B+—for treating HIV+ pregnant women. While efficacy has been demonstrated in randomized trials, there is limited real-world evidence on the impact of these changes. Using longitudinal, routinely collected data we assessed the impact of the adoption of WHO Option B in Rwanda on mother to infant transmission. Methods: We used interrupted time series analysis to evaluate the impact of Option B on mother-to-child HIV transmission in Rwanda. Our primary outcome was the proportion of HIV tests in infants with positive results at six weeks of age. We included data for 20 months before and 22 months after the 2010 policy change. Results: Of the 15,830 HIV tests conducted during our study period, 392 tested positive. We found a significant decrease in both the level (-2.08 positive tests per 100 tests conducted, 95% CI: -2.71 to -1.45, p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0192910

DOI: 10.1371/journal.pone.0192910

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