Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study

Sue K Park, Cedric F Garland, Edward D Gorham, Luke BuDoff and Elizabeth Barrett-Connor

PLOS ONE, 2018, vol. 13, issue 4, 1-17

Abstract: Background: It has been reported that higher plasma 25-hydroxyvitamin D is associated with lower risk of type 2 diabetes. However the results to date have been mixed and no adequate data based on a cohort are available for the high end of the normal range, above approximately 32 ng/ml or 80 nmol/L. Methods: We performed a cohort study of 903 adults who were known to be free of diabetes or pre-diabetes during a 1997–1999 visit to a NIH Lipid Research Centers clinic. Plasma 25(OH)D was measured at Visit 8 in 1977–1979. The mean age was 74 years. The visit also included fasting plasma glucose and oral glucose tolerance testing. Results: There were 47 cases of diabetes and 337 cases of pre-diabetes. Higher 25(OH)D concentrations (> 30 ng/ml) were associated with lower hazard ratios (HR) for diabetes: 30–39 ng/ml or 75–98 nmol/L: HR = 0.31, 95% CI = 0.14–0.70; for 40–49 ng/ml or 100–122 nmol/L: HR = 0.29, CI = 0.12–0.68; for > 50 ng/ml or 125 nmol/L: HR = 0.19, CI = 0.06–0.56. All HRs are compared to

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0193070

DOI: 10.1371/journal.pone.0193070

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