Impact of 9p deletion and p16, Cyclin D1, and Myc hyperexpression on the outcome of anaplastic oligodendrogliomas

Karine Michaud, Marie de Tayrac, Myreille D’Astous, Claudie Paquet, Peter Vincent Gould and Stéphan Saikali

PLOS ONE, 2018, vol. 13, issue 2, 1-18

Abstract: Objective: To study the presence of 9p deletion and p16, cyclin D1 and Myc expression and their respective diagnostic and prognostic interest in oligodendrogliomas. Methods: We analyzed a retrospective series of 40 consecutive anaplastic oligodendrogliomas (OIII) from a single institution and compared them to a control series of 10 low grade oligodendrogliomas (OII). Automated FISH analysis of chromosome 9p status and immunohistochemistry for p16, cyclin D1 and Myc was performed for all cases and correlated with clinical and histological data, event free survival (EFS) and overall survival (OS). Results: Chromosome 9p deletion was observed in 55% of OIII (22/40) but not in OII. Deletion was highly correlated to EFS (median = 29 versus 53 months, p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0193213

DOI: 10.1371/journal.pone.0193213

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