Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

Steven W Lee, Kanchan Kulkarni, Elizabeth M Annoni, Imad Libbus, Bruce H KenKnight and Elena G Tolkacheva

PLOS ONE, 2018, vol. 13, issue 3, 1-17

Abstract: Vagus nerve stimulation (VNS) is an approved therapy for treatment of epilepsy and depression. While also shown to be promising in several preclinical and clinical studies to treat cardiovascular diseases, optimal therapeutic stimulation paradigms are still under investigation. Traditionally, parameters such as frequency, current, and duty cycle are used to adjust the efficacy of VNS therapy. This study explored the effect of novel stochastic VNS (S-VNS) on acute heart rate (HR) dynamics. The effect of S-VNS was evaluated in Sprague Dawley rats by comparing the acute HR and HR variability (HRV) responses to standard, periodic VNS (P-VNS) across different frequencies (FREQs, 10–30 Hz). Our results demonstrate that both S-VNS and P-VNS produced negative chronotropic effects in a FREQ-dependent manner with S-VNS inducing a significantly smaller drop in HR at 10 Hz and 20 Hz compared to P-VNS (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0194910

DOI: 10.1371/journal.pone.0194910

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