Clinical outcomes and predictors of response to photodynamic therapy in symptomatic circumscribed choroidal hemangioma: A retrospective case series

Yeen-Fey Ho, Anne Chao, Kuan-Jen Chen, An-Ning Chao, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai and Tun-Lu Chen

PLOS ONE, 2018, vol. 13, issue 5, 1-10

Abstract: Background: To investigate the treatment outcomes and predictors of response to photodynamic therapy (PDT) in patients with symptomatic circumscribed hemangioma (CCH). Methods: This retrospective case series examined 20 patients with symptomatic CCH (10 submacular CCHs and10 juxtapapillary CCHs) who underwent standard PDT (wavelength: 662 nm; light dose: 50J/cm2; exposure time: 83 sec) with verteporfin (6mg/m2), either as monotherapy (n = 9) or in association with other treatments (n = 11), of which 7 received intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF). A post-PDT improvement of at least two lines in best-corrected visual acuity (BCVA) was the primary outcome measure. Predictors of response were investigated with binary logistic regression analysis. Results: Seventeen (85%) patients received one PDT session, and three patients (15%) underwent PDT at least twice. Ten patients (50%) achieved the primary outcome of a post-PDT BCVA improvement of at least two lines. Macular atrophy and recalcitrant cystoid macular edema in 2 patients. Binary logistic regression analysis revealed that younger age (

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0197088

DOI: 10.1371/journal.pone.0197088

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