Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model

Francesca Troiani, Konstantin Nikolic and Timothy G Constandinou

PLOS ONE, 2018, vol. 13, issue 7, 1-14

Abstract: We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). The OCT output signal is created using two different simulations for the reference and sample arms, with a successive computation of the interference signal with external software. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work aims to understand to what extent time domain OCT can be used for non-invasive, direct optical monitoring of peripheral nerve activity.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0200392

DOI: 10.1371/journal.pone.0200392

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