A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder

Satoshi Yamada, Tomohiro Nakao, Keisuke Ikari, Masumi Kuwano, Keitaro Murayama, Hirofumi Tomiyama, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi and Shigenobu Kanba

PLOS ONE, 2018, vol. 13, issue 7, 1-13

Abstract: Background: Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. Methods: Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. Results: The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0200814

DOI: 10.1371/journal.pone.0200814

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