Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging

Irene A Burger, Christine Lohmann, Michael Messerli, Susan Bengs, Anton Becker, Monika Maredziak, Valerie Treyer, Ahmed Haider, Moritz Schwyzer, Dominik C Benz, Ken Kudura, Michael Fiechter, Andreas A Giannopoulos, Tobias A Fuchs, Christoph Gräni, Aju P Pazhenkottil, Oliver Gaemperli, Ronny R Buechel, Philipp A Kaufmann and Catherine Gebhard

PLOS ONE, 2018, vol. 13, issue 8, 1-14

Abstract: Background: Sexual dimorphism in cardiac sympathetic outflow has recently gained attention in the context of Takotsubo cardiomyopathy. Previous studies suggest that there are sex- and age-dependent differences in peripheral autonomic control, however, data on cardiac-specific sympathetic activation in aged women and men are lacking. Methods and results: Regional quantitative analysis of cardiac fluorine-18 (18F)- Dihydroxyphenylalanine (DOPA) uptake was retrospectively performed in 133 patients (69 females, mean age 52.4±17.7 years) referred for assessment of neuroendocrine tumours (NET) by Positron-Emission-Tomography. Cardiac 18F-DOPA uptake was significantly higher in women as compared to men (1.33±0.21 vs. 1.18±0.24, p 55 years of age (1.39±0.25 in women vs. 1.09±0.24 in men, p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0202302

DOI: 10.1371/journal.pone.0202302

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