Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study

Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won and Hyoung Woo Lee

PLOS ONE, 2018, vol. 13, issue 8, 1-13

Abstract: Introduction: Low urine pH (UpH) and high serum uric acid are considered evidence of metabolic disorders. The effect of low UpH on the development of metabolic syndrome (MetS) is less clear than that of high serum uric acid. We investigated the association between low UpH on the development of MetS and its components: central obesity, dyslipidemia, hypertension, and dysglycemia. Methods: Two studies were conducted based on 2 datasets. The cross-sectional study included 14,511 subjects aged 19–80 years, based on the Korea National Health and Nutrition Examination Survey in 2013–2015. The retrospective cohort study included 3,453 subjects aged 19–80 years without MetS at the first checkup, who underwent at least 3 health checkups at a single tertiary hospital between 2011 and 2017. UpH was measured using an automatic urine analyzer in the range of 5.0–9.0 at first visit. Results: In the cross-sectional study, low UpH (= 5.0) was associated with the prevalence of MetS (odds ratio [OR] = 1.480, 95% confidence interval [CI] 1.334–1.643, p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0202757

DOI: 10.1371/journal.pone.0202757

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