Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study

Zheng-Liang Peng, Liang-Wei Huang, Jian Yin, Ke-Na Zhang, Kang Xiao and Guo-Zhong Qing

PLOS ONE, 2018, vol. 13, issue 8, 1-14

Abstract: Low serum cholinesterase (SCHE) activity has been associated with poor prognoses in a variety of conditions, including sepsis. However, such an association has not been well characterized since the Third International Consensus Definitions Task Force modified the definition of sepsis to “life-threatening organ dysfunction due to a dysregulated host response to infection” (known as sepsis-3) in 2016. In the current retrospective cohort study, we examined whether 30-day mortality in sepsis-3 patients is associated with SCHE activity. A total of 166 sepsis-3 patients receiving treatment at an emergency intensive care unit (EICU) were included. The 30-day death rate was 33.1% (55/166). SCHE activity upon EICU admission was lower in nonsurvivors (3.3 vs. 4.5 KU/L in survivors, p = 0.0002). Subjects with low SCHE activity (defined as

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0203128

DOI: 10.1371/journal.pone.0203128

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