Realtime phase-amplitude coupling analysis of micro electrode recorded brain signals

David Chao-Chia Lu, Chadwick Boulay, Adrian D C Chan and Adam J Sachs

PLOS ONE, 2018, vol. 13, issue 9, 1-16

Abstract: Objective: To demonstrate a method to calculate phase amplitude coupling (PAC) quickly and robustly for realtime applications. Methods: We designed and implemented a multirate PAC algorithm with efficient filter bank processing and efficient computation of PAC for many frequency-pair combinations. We tested the developed algorithm for computing PAC on simulated data and on intraoperative neural recording data obtained during deep brain stimulation (DBS) electrode implantation surgery. Results: A combination of parallelized frequency-domain filtering and modulation index for PAC estimation provided robust results that could be calculated in real time on modest computing hardware. Conclusion: The standard methods for calculating PAC can be optimized for quick and robust performance. Significance: These results demonstrated that PAC can be extracted in real time and is suitable for neurofeedback applications.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0204260

DOI: 10.1371/journal.pone.0204260

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