Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery

Patrycja Krzyżanowska-Berkowska, Karolina Czajor, Iwona Helemejko and D Robert Iskander

PLOS ONE, 2018, vol. 13, issue 11, 1-15

Abstract: Purpose: To assess whether lamina cribrosa depth (LCD) reduction and the rate of change in LCD over time (ΔLCD/Δt) is associated with retinal nerve fiber layer (RNFL) thickness and the rate of RNFL thinning over time (ΔRNFL/Δt) to test the hypothesis that, in a long term, RNFL thinning occurs irrespectively to the displacement of the lamina cribrosa following glaucoma surgery. Methods: Twenty-nine primary open-angle glaucoma patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy and 13 patients undertook non-penetrating deep sclerectomy. Images of optic nerve head using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging technology were obtained preoperatively, at one-, three-, six-month and follow-up postoperative visit from 12 to 29 months after surgery (1pv, 3pv, 6pv, and FUpv, respectively). Correspondingly, measurements of the circumpapillary RNFL thickness were acquired. Results: Intraocular pressure decreased from 24.0±8.9 to 10.9±3.9mmHg at 6pv (P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0206040

DOI: 10.1371/journal.pone.0206040

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