Validation of a low-cost, carbon dioxide-based cryoablation system for percutaneous tumor ablation

Bailey Surtees, Sean Young, Yixin Hu, Guannan Wang, Evelyn McChesney, Grace Kuroki, Pascal Acree, Serena Thomas, Tara Blair, Shivam Rastogi, Dara L Kraitchman, Clifford Weiss, Saraswati Sukumar, Susan C Harvey and Nicholas J Durr

PLOS ONE, 2019, vol. 14, issue 7, 1-12

Abstract: Breast cancer rates are rising in low- and middle-income countries (LMICs), yet there is a lack of accessible and cost-effective treatment. As a result, the cancer burden and death rates are highest in LMICs. In an effort to meet this need, our work presents the design and feasibility of a low-cost cryoablation system using widely-available carbon dioxide as the only consumable. This system uses an 8-gauge outer-diameter needle and Joule-Thomson expansion to percutaneously necrose tissue with cryoablation. Bench top experiments characterized temperature dynamics in ultrasound gel demonstrated that isotherms greater than 2 cm were formed. Further, this system was applied to mammary tumors in an in vivo rat model and necrosis was verified by histopathology. Finally, freezing capacity under a large heat load was assessed with an in vivo porcine study, where volumes of necrosis greater than 1.5 cm in diameter confirmed by histopathology were induced in a highly perfused liver after two 7-minute freeze cycles. These results demonstrate the feasibility of a carbon-dioxide based cryoablation system for improving solid tumor treatment options in resource-constrained environments.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0207107

DOI: 10.1371/journal.pone.0207107

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