Dosimetric and radiobiological comparison in different dose calculation grid sizes between Acuros XB and anisotropic analytical algorithm for prostate VMAT

Kyeong-Hyeon Kim, Jin-Beom Chung, Tae Suk Suh, Sang-Won Kang, Seong-Hee Kang, Keun-Yong Eom, Changhoon Song, In-Ah Kim and Jae-Sung Kim

PLOS ONE, 2018, vol. 13, issue 11, 1-18

Abstract: To investigate feasible treatment planning parameters, we aimed to evaluate the dosimetric and radiobiological impact of the dose calculation algorithm and grid size in the volumetric modulated arc therapy (VMAT) plan for prostate cancer. Twenty patients were selected, and the treatment plans were initially generated with anisotropic analytical algorithm (AAA) and recalculated with Acuros XB (AXB) algorithm. Various dose grids were used for AXB (1, 2, and 3 mm) and AAA (1, 3, and 5 mm) plan. Dosimetric parameters such as homogeneity index (HI) and conformity index (CI), and radiobiological parameters such as tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated. Significant differences were observed in the planning target volume (PTV) coverage between both algorithms, and the V95%, HI, and CI of AAA were significantly affected by grid (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0207232

DOI: 10.1371/journal.pone.0207232

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