Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study

Norma C Serrano, Doris Cristina Quintero-Lesmes, Silvia Becerra-Bayona, Elizabeth Guio, Mónica Beltran, María C Paez, Ricardo Ortiz, Wilmar Saldarriaga, Luis A Diaz, Álvaro Monterrosa, Jezid Miranda, Clara M Mesa, José E Sanin, German Monsalve, Frank Dudbridge, Aroon D Hingorani and Juan P Casas

PLOS ONE, 2018, vol. 13, issue 12, 1-15

Abstract: Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Materials and methods: Design: A case-control study. Results: After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy. Conclusions: Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0208137

DOI: 10.1371/journal.pone.0208137

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