Maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates: A meta-analysis

Dongqiong Xiao, Tingting Zhu, Yi Qu, Xiaoyun Gou, Qun Huang, Xihong Li and Dezhi Mu

PLOS ONE, 2018, vol. 13, issue 12, 1-14

Abstract: Context: No consensus exists regarding the association between maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates. Objectives: To investigate whether maternal chorioamnionitis affects neurodevelopmental outcomes and to identify the factors that may explain these effects. Data sources: We used Ovid Medline, EMBASE and Web of Science to conduct a meta-analysis of studies published in English before August 25, 2017, with titles or abstracts that discussed an association between maternal chorioamnionitis and mental/motor development. Study selection: Among the 603 initially identified studies, we selected those that addressed an association between maternal chorioamnionitis and mental/motor development according to our preselected inclusion criteria as follows: (1) the study compared infants with and without exposure to maternal chorioamnionitis and (2) the neurodevelopmental outcome was followed up using the Bayley Scales of Infant Development 2nd edition. Data synthesis: Our meta-analysis included 10 studies. According to a random effect model, infants with maternal chorioamnionitis exposure had poorer mental development (d = -2.25 [95%CI, -4.33, -0.17], p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0208302

DOI: 10.1371/journal.pone.0208302

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