The role of surgery in stage I to III small cell lung cancer: A systematic review and meta-analysis

Tingting Liu, Zihao Chen, Jun Dang and Guang Li

PLOS ONE, 2018, vol. 13, issue 12, 1-13

Abstract: Background: The role of surgery in treating small cell lung cancer (SCLC) remains controversial. This meta-analysis aims to determine whether surgical-based treatment improves survival in comparison to radiotherapy, chemotherapy, and chemoradiotherapy for stage I to III SCLC. Methods: PubMed, PubMed Central, EMBASE, Web of Science, and Cochrane Library were searched for relevant articles. The main outcome were overall survival (OS), reported as hazard ratios (HRs), and 95% confidence intervals (CIs). Results: Two randomized control trials (RCTs) and 13 retrospective studies that included a total of 41,483 patients were eligible. Surgical resection significantly improved OS when compared to non-surgical treatment in retrospective studies (HR = 0.56, 95% CI: 0.49–0.64, P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0210001

DOI: 10.1371/journal.pone.0210001

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