Prevalence of Chagas disease in Colombia: A systematic review and meta-analysis

Mario J Olivera, Johana A Fory, Julián F Porras and Giancarlo Buitrago

PLOS ONE, 2019, vol. 14, issue 1, 1-18

Abstract: Background: Despite the adoption of campaigns to interrupt the main vector and to detect Trypanosoma cruzi in blood banks, millions of people are still chronically infected; however, the prevalence data are limited, and the epidemiology of Chagas disease has not been systematically evaluated. This study aimed to estimate the prevalence of Chagas disease in Colombia. Methods: A systematic literature review and meta-analysis was conducted to select all observational studies reporting the prevalence of Chagas disease in Colombia, based on serological diagnosis in participants of any age and published between January 2007 and November 2017. Pooled estimates and 95% confidence intervals (95% CIs) were calculated using random-effects models. In addition, the I2 statistic was calculated. Results: The literature search yielded a total of 1,510 studies; sixteen articles with relevant prevalence data were included in the systematic review. Of these, only 12 articles were included for entry in the meta-analysis. The pooled prevalence of Chagas disease across studies was 2.0% (95% CI: 1.0–4.0). A high degree of heterogeneity was found among studies (I2 > 75%; p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0210156

DOI: 10.1371/journal.pone.0210156

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