Cancer risk in children and young adults born preterm: A systematic review and meta-analysis

Katryn Paquette, Hallie Coltin, Ariane Boivin, Devendra Amre, Anne-Monique Nuyt and Thuy Mai Luu

PLOS ONE, 2019, vol. 14, issue 1, 1-15

Abstract: Introduction: Risk of developing a malignancy when born premature is unknown. We hypothesised that risk of certain cancers might be increased in youth born preterm versus term. We therefore performed a systematic review and meta-analysis to evaluate the incidence of malignancy in the context of preterm birth, according to various cancer types. Methods: The study was designed per MOOSE and PRISMA guidelines. Articles were identified through November 2015. Observational studies exploring the association between childhood malignancy and birth characteristics were included. Of the 1658 records identified, 109 full text articles were evaluated for eligibility. Random effects meta-analyses were conducted on 10/26 studies retained; 95% confidence intervals were computed and adjusted following sensitivity analysis. Publication bias was evaluated using funnel plots, Begg’s and Egger’s tests. Results: No differences in risk of primary central nervous system tumor [OR 1.05; 95% CI 0.93–1.17, 5 studies, 580 cases] and neuroblastoma [OR 1.09; 95% CI 0.90–1.32, 5 studies, 211 cases] were observed in individuals born

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0210366

DOI: 10.1371/journal.pone.0210366

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