Estimation of intravoxel incoherent motion parameters using low b-values

Chen Ye, Daoyun Xu, Yongbin Qin, Lihui Wang, Rongpin Wang, Wuchao Li, Zixiang Kuai and Yuemin Zhu

PLOS ONE, 2019, vol. 14, issue 2, 1-16

Abstract: Intravoxel incoherent motion (IVIM) imaging is a magnetic resonance imaging (MRI) technique widely used in clinical applications for various organs. However, IVIM imaging at low b-values is a persistent problem. This paper aims to investigate in a systematic and detailed manner how the number of low b-values influences the estimation of IVIM parameters. To this end, diffusion-weighted (DW) data with different low b-values were simulated to get insight into the distributions of subsequent IVIM parameters. Then, in vivo DW data with different numbers of low b-values and different number of excitations (NEX) were acquired. Finally, least-squares (LSQ) and Bayesian shrinkage prior (BSP) fitting methods were implemented to estimate IVIM parameters. The influence of the number of low b-values on IVIM parameters was analyzed in terms of relative error (RE) and structural similarity (SSIM). The results showed that the influence of the number of low b-values on IVIM parameters is variable. LSQ is more dependent on the number of low b-values than BSP, but the latter is more sensitive to noise.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0211911

DOI: 10.1371/journal.pone.0211911

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