Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: Comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance

Cleliani de Cassia da Silva, Mariana Porto Zambon, Ana Carolina Junqueira Vasques, Daniella Fernandes Camilo, Ana Maria De Bernardi Rodrigues, Maria Ângela Reis de Góes Monteiro Antonio, Ana Raimunda Dâmaso, Sergio Tufik, Marco Tulio de Mello, Raquel Munhoz da Silveira Campos, Bruno Geloneze and for the Brazilian Metabolic Syndrome Study (BRAMS) Investigators

PLOS ONE, 2019, vol. 14, issue 3, 1-12

Abstract: Background: Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated. Objectives: To evaluate the association between the HOMA-Adiponectin and the insulin resistance assessed by the glucose clamp technique in adolescents, and to compare the accuracy of HOMA-Adiponectin and HOMA-insulin resistance (HOMA-IR) for identifying insulin resistance. Methods: This was a cross-sectional study of 56 adolescents (aged 10–18 years). Insulin resistance was assessed using the HOMA-IR, HOMA-Adiponectin and the hyperglycaemic clamp technique. The clamp-derived insulin sensitivity index, HOMA-Adiponectin, and HOMA-IR were log-transformed to get closer to a normal distribution before analysis. Results: In the multivariable linear regression analysis controlling for sex and Tanner stage, HOMA-Adiponectin was inversely associated with the clamp-derived insulin sensitivity index (unstandardized coefficient [B] = -0.441; P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0214081

DOI: 10.1371/journal.pone.0214081

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