The mTST – An mHealth approach for training and quality assurance of tuberculin skin test administration and reading

Saeedeh Moayedi-Nia, Leila Barss, Olivia Oxlade, Chantal Valiquette, Mei-Xin Ly, Jonathon R Campbell, Zhiyi Lan, Placide Nsengiyumva, Federica Fregonese, Mayara Lisboa Bastos, Danielle Sampath, Nicholas Winters and Dick Menzies

PLOS ONE, 2019, vol. 14, issue 4, 1-13

Abstract: Background: The Tuberculin Skin Test (TST) is a relatively simple test for detecting latent tuberculosis infection (LTBI) but requires regular quality assurance to ensure proper technique for administration and reading. The objective of this study was to estimate the accuracy and reproducibility of an mhealth approach (the mTST) to measure the size of swelling immediately following TST administration (TST injection bleb) and after 48–72 hours (TST induration). Methods: Five non-clinical and one clinical reviewer measured the size of TST injection blebs, and TST indurations using smartphone acquired photos of sites of TST administration and readings in patients, or saline injections in volunteers. The reference standard was the onsite measurement (measured by an experienced TB nurse) of the actual TST injection bleb, or induration. Agreement of reviewers’ measurements with the reference standard, as well as agreement within and between reviewers, was estimated using Cohen's kappa coefficient. Results: Using the mTST method to assess bleb size in 64 photos of different TST injections, agreement between reviewers, and the reference standard was very good to excellent (κ ranged from 0.75 to 0.87), and within-reviewer reproducibility of readings was excellent (κ ranged from 0.86 to 0.96). Using the mTST method to assess TST induration in 72 photos, reviewers were able to detect no induration (

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0215240

DOI: 10.1371/journal.pone.0215240

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