Association of IBD specific treatment and prevalence of pain in the Swiss IBD cohort study

Lorenz Bon, Sylvie Scharl, Stephan Vavricka, Gerhard Rogler, Nicolas Fournier, Valerie Pittet, Michael Scharl, Thomas Greuter, Philipp Schreiner, Pascal Frei, Benjamin Misselwitz, Luc Biedermann, Jonas Zeitz and for the Swiss IBD Cohort Study Group

PLOS ONE, 2019, vol. 14, issue 4, 1-12

Abstract: Background: Extraintestinal manifestations (EIM) contribute significantly to the burden of disease in inflammatory bowel disease (IBD). Pain is a leading symptom in IBD and could be seen as an EIM itself. Treatment of IBD associated pain is challenging and insufficiently studied. A better knowledge on the association of pain and IBD specific treatment is warranted to improve the management of IBD patients. Methods: All patients of the Swiss IBD Cohort Study (SIBDCS) (n = 2152) received a questionnaire regarding pain localization, pain character, and the use of IBD specific medication. Results: 1263 completed questionnaires were received. Twenty-one out of 184 patients (10%) receiving anti-TNF treatment compared to 142 out of 678 patients (21%) not receiving anti-TNF medication reported elbow pain (p = 0.002) while 28 out of 198 patients (14%) receiving steroid treatment significantly more often reported elbow pain compared to 59 from 696 patients (8%) not receiving steroids (p = 0.021). Furthermore, we found significantly more female patients under anti-TNF treatment to report knee/ lower leg pain and ankle/ foot pain compared to their male counterparts (36% vs. 20% and 22% vs. 10%, respectively, p = 0.015 for both comparisons). The frequency of knee, lower leg, ankle and foot pain was especially low in male patients under anti-TNF treatment, indicating a high benefit of male patients from anti-TNF therapy regarding EIM. Conclusions: The frequency of elbow pain was lower in IBD patients treated with anti-TNF but higher in patients treated with steroids.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0215738

DOI: 10.1371/journal.pone.0215738

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