EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study

A Martin-Cardona, G Fernandez-Esparrach, J C Subtil, J Iglesias-Garcia, M Garcia-Guix, A Barturen Barroso, A Z Gimeno-Garcia, J M Esteban, A Pardo Balteiro, A Velasco-Guardado, E Vazquez-Sequeiros, C Loras, B Martinez-Moreno, A Castellot, C Huertas, M Martinez-Lapiedra, A Sanchez-Yague, A Teran, V J Morales-Alvarado, M Betes, D de la Iglesia, C Sánchez-Montes, M D Lozano, J Lariño-Noia, A Gines, C Tebe, J B Gornals and On belhaf of Spanish Group for EUS-Guided TA in the adrenal Gland

PLOS ONE, 2019, vol. 14, issue 6, 1-16

Abstract: Background: There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy. Methods: This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist’s suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy. Results: A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. Conclusions: EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0216658

DOI: 10.1371/journal.pone.0216658

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