Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

Hans-Jonas Meyer, Andreas Wienke and Alexey Surov

PLOS ONE, 2019, vol. 14, issue 6, 1-16

Abstract: Purpose: Fluorodeoxyglucose-Positron-emission tomography (FDG-PET), quantified by standardized uptake values (SUV), is one of the most used functional imaging modality in clinical routine. It is widely acknowledged to be strongly associated with Glucose-transporter family (GLUT)-expression in tumors, which mediates the glucose uptake into cells. The present systematic review sought to elucidate the association between GLUT 1 and 3 expression with SUV values in various tumors. Methods: MEDLINE library was screened for associations between FDG-PET parameters and GLUT correlation cancer up to October 2018. Results: There were 53 studies comprising 2291 patients involving GLUT 1 expression and 11 studies comprising 405 patients of GLUT 3 expression. The pooled correlation coefficient for GLUT 1 was r = 0.46 (95% CI 0.40–0.52), for GLUT 3 was r = 0.35 (95%CI 0.24–0.46). Thereafter, subgroup analyses were performed. The highest correlation coefficient for GLUT 1 was found in pancreatic cancer r = 0.60 (95%CI 0.46–0.75), the lowest was identified in colorectal cancer with r = 0.21 (95% CI -0.57–0.09). Conclusion: An overall only moderate association was found between GLUT 1 expression and SUV values derived from FDG-PET. The correlation coefficient with GLUT 3 was weaker. Presumably, the underlying mechanisms of glucose hypermetabolism in tumors are more complex and not solely depended on the GLUT expression.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0217781

DOI: 10.1371/journal.pone.0217781

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