Differences in biological behaviors between young and elderly patients with colorectal cancer

Chinock Cheong, Seung Yeop Oh, Young Bae Kim and Kwang Wook Suh

PLOS ONE, 2019, vol. 14, issue 6, 1-11

Abstract: Background: We investigated the differences in biological behaviors of sporadic colorectal cancer (CRC) between young and elderly patients. CRC is a common cancer, with a mean age at onset of > 65 years. However, recent reports indicate increasing rates in younger populations. The biological behaviors of sporadic CRC in elderly patients could differ from those in young patients. Methods: Between September 2007 and August 2012, we selected 723 CRC patients from our institution. The patients were divided into Group Y (n = 127, aged ≤50 years) and Group O (n = 596, aged >50 years). The clinicopathologic and oncologic outcomes in the two groups were compared. Results: Group Y tumors were characterized by higher incidences of mucin production (13.4% vs. 6.7%; P = 0.017), high microsatellite instability (MSI-H) (19.8% vs. 5.2%; P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0218604

DOI: 10.1371/journal.pone.0218604

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