Genetic and clinical predictors of CD4 lymphocyte recovery during suppressive antiretroviral therapy: Whole exome sequencing and antiretroviral therapy response phenotypes

Ruth Greenblatt, Peter Bacchetti, Ross Boylan, Kord Kober, Gayle Springer, Kathryn Anastos, Michael Busch, Mardge Cohen, Seble Kassaye, Deborah Gustafson, Bradley Aouizerat and on behalf of the Women’s Interagency HIV Study

PLOS ONE, 2019, vol. 14, issue 8, 1-25

Abstract: Increase of peripheral blood CD4 lymphocyte counts is a key goal of combined antiretroviral therapy (cART); most, but not all, recipients respond adequately and promptly. A small number of studies have examined specific genetic factors associated with the extent of CD4 recovery. We report a genome-wide examination of factors that predict CD4 recovery in HIV-infected women. We identified women in in a cohort study who were on cART with viral load below 400 copies, and drew racially and ethnically matched samples of those with good CD4 response over 2 years or poor response. We analyzed the exomes of those women employing next generation sequencing for genes associated with CD4 recovery after controlling for non-genetic factors identified through forward stepwise selection as important. We studied 48 women with good CD4 recovery and 42 with poor CD4 recovery during virologically-suppressive cART. Stepwise logistic regression selected only age as a statistically significant (p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0219201

DOI: 10.1371/journal.pone.0219201

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