Hematological and biochemical parameters for Chinese rhesus macaque

Wenhai Yu, Xianhui Hao, Fengmei Yang, Jin Ma, Yuan Zhao, Yanyan Li, Junbin Wang, Hongjie Xu, Lixiong Chen, Quan Liu, Suqin Duan, Yaping Yang, Fen Huang and Zhanlong He

PLOS ONE, 2019, vol. 14, issue 9, 1-15

Abstract: Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0222338

DOI: 10.1371/journal.pone.0222338

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