Alteration of the anatomical covariance network after corpus callosotomy in pediatric intractable epilepsy

Riyo Ueda, Hiroshi Matsuda, Noriko Sato, Masaki Iwasaki, Daichi Sone, Eri Takeshita, Yuko Shimizu-Motohashi, Akihiko Ishiyama, Takashi Saito, Hirofumi Komaki, Eiji Nakagawa, Kenji Sugai, Masayuki Sasaki, Yoshimi Kaga, Hiroshige Takeichi and Masumi Inagaki

PLOS ONE, 2019, vol. 14, issue 12, 1-14

Abstract: Purpose: This study aimed to use graph theoretical analysis of anatomical covariance derived from structural MRI to reveal how the gray matter connectivity pattern is altered after corpus callosotomy (CC). Materials and methods: We recruited 21 patients with epilepsy who had undergone CC. Enrollment criteria were applied: (1) no lesion identified on brain MRI; (2) no history of other brain surgery; and (3) age not younger than 3 years and not older than 18 years at preoperative MRI evaluation. The most common epilepsy syndrome was Lennox-Gastaut syndrome (11 patients). For voxel-based morphometry, the normalized gray matter images of pre-CC and post-CC patients were analyzed with SPM12 (voxel-level threshold of p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0222876

DOI: 10.1371/journal.pone.0222876

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