Preference-based measure of health-related quality of life and its determinants in sickle cell disease in Nigeria

Adedokun Oluwafemi Ojelabi, Afolabi Elijah Bamgboye and Jonathan Ling

PLOS ONE, 2019, vol. 14, issue 11, 1-16

Abstract: Background: Health-related quality of life (HRQL) and economic burden are important issues for people with sickle cell disease (SCD) owing to better survival due to medical advances. Preference-based or utility information is necessary to make informed economic decisions on treatment and alternative therapies. This study aimed to assess preference-based measures of HRQL in sickle cell patients. Methods and findings: Data were collected from two SCD outpatient clinics in Ibadan, Nigeria. A standard algorithm was used to derive utility scores, and measure SF-6D from the SF-36. A multivariate regression model was used to assess predictors and their impact. A combination of socio-demographic, bio-physiological and psychosocial variables predicted utility score in people with SCD. Socio-demographic and bio-physiological factors explained 7.5% and 17.9% of the variance respectively, while psychosocial factors explained 4.9%. Women had lower utility scores with a small effect size (d = 0.17). Utility score increased with level of education but decreased with age, anxiety, frequency of pain episodes and number of co-morbidities. Conclusions: Utility score in SCD was low indicating a substantial impact of the disease on HRQL of patients and the value they place on their health state due to the limitations they experienced. Interventions should include both clinical and psychosocial approach to help in improving their quality of life of the patients.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0223043

DOI: 10.1371/journal.pone.0223043

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