Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials

Mingyang Yu, Rongguang Zhang, Peng Ni, Shuaiyin Chen and Guangcai Duan

PLOS ONE, 2019, vol. 14, issue 10, 1-16

Abstract: Aim: To assess the effect of Lactobacillus supplementation on Helicobacter pylori eradication rates and side effects of the triple therapy. Methods: PubMed, Embase, Web of Science and Cochrane Library were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. Results: The initial database search resulted in 852 articles. Through exclusion and screening, 11 randomized controlled trials involving a total of 724 patients were finally included in this meta-analysis. The H. pylori elimination rate in the Lactobacillus supplement group was significantly higher than that in the control group (RR 1.16, 95% CI 1.08–1.25, P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0223309

DOI: 10.1371/journal.pone.0223309

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